PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3cccc(C(=O)N4CCC(N5CC=C(c6cccc(Cl)c6Cl)CC5)C(F)(F)C4)c3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C000960

FormulaC30H26Cl2F2N4O5

Molecular weight631.463

InChIKeyFICOSLYJPBCQLC-UHFFFAOYSA-N

Physicochemical properties

Exact mass630.1248

RDKit cLogP4.03

TPSA107.1

HBD / HBA1 / 6

Rotatable bonds4

Heavy atoms43

Hetero atoms13

Rings / aromatic6 / 2

Fraction Csp30.37

Formal charge0

Fragments1

Activity compounds and values

Activity records

6 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	CN120548310A	PGDB_A012803	PGDB_C000960	PGDB_AS001449	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	CN120548310A	PGDB_A014836	PGDB_C000960	PGDB_AS000102	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	CN120548310A	PGDB_A018767	PGDB_C000960	PGDB_AS001466	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	CN120548310A	PGDB_A019358	PGDB_C000960	PGDB_AS002025	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	CN120548310A	PGDB_A019649	PGDB_C000960	PGDB_AS000946	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	CN120548310A	PGDB_A024053	PGDB_C000960	PGDB_AS001655	View

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