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Compound
PGDB_C001866
10 activity records1 related patents
2D structure
COCCOc1cc(NC(=O)NCc2ccc3c(C4CCC(=O)NC4=O)noc3c2)cc(Cl)c1CCompound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % Inhibition | - | = | 70.53 | % | - | 3 d | GSPT1 | - | NCI-H69 | WO2023001028A1 | PGDB_A009183 | PGDB_C001866 | PGDB_AS002018 | View |
| % Inhibition | - | = | 99.37 | % | - | 3 d | GSPT1 | - | NCI-H526 | WO2023001028A1 | PGDB_A028193 | PGDB_C001866 | PGDB_AS000350 | View |
| IC50 | - | = | 1.3 | nM | - | — | GSPT1 | - | NCI-H1581 | WO2023001028A1 | PGDB_A028416 | PGDB_C001866 | PGDB_AS000790 | View |
| % Inhibition | - | = | 87.56 | % | - | 3 d | GSPT1 | - | DMS114 | WO2023001028A1 | PGDB_A034972 | PGDB_C001866 | PGDB_AS001771 | View |
| % Degradation | - | = | 100.36 | % | - | 18 h | GSPT1 | - | HEK293T | WO2023001028A1 | PGDB_A035775 | PGDB_C001866 | PGDB_AS000448 | View |
| IC50 | - | = | 1.3 | nM | - | — | GSPT1 | - | NCI-H69 | WO2023001028A1 | PGDB_A039645 | PGDB_C001866 | PGDB_AS001964 | View |
| % Inhibition | - | = | 88.62 | % | - | 3 d | GSPT1 | - | NCI-H1581 | WO2023001028A1 | PGDB_A052421 | PGDB_C001866 | PGDB_AS000288 | View |
| IC50 | - | = | 0.1 | nM | - | — | GSPT1 | - | NCI-H526 | WO2023001028A1 | PGDB_A052632 | PGDB_C001866 | PGDB_AS001706 | View |
| DC50 | - | = | 1.07 | nM | - | — | GSPT1 | - | HEK293T | WO2023001028A1 | PGDB_A056005 | PGDB_C001866 | PGDB_AS002023 | View |
| IC50 | - | = | 2.1 | nM | - | — | GSPT1 | - | DMS114 | WO2023001028A1 | PGDB_A063915 | PGDB_C001866 | PGDB_AS000425 | View |