PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

N#Cc1ccc(N2CCN(Cc3ccc(Cc4ccc5c6c(cc(F)cc46)C(=O)N5[C@H]4CCC(=O)NC4=O)cc3)CC2)c(F)c1

Compound summary

Compound IDPGDB_C007553

FormulaC35H29F2N5O3

Molecular weight605.645

InChIKeyHULAZOQCQMEDII-HKBQPEDESA-N

Physicochemical properties

Exact mass605.2238

RDKit cLogP4.67

TPSA96.8

HBD / HBA1 / 6

Rotatable bonds6

Heavy atoms45

Hetero atoms10

Rings / aromatic7 / 4

Fraction Csp30.26

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	90.9	%	Concentration context: HiBiT IKZF1:_D max (%)	20 h	IKZF1	-	HT-1080	EP4393915A1	PGDB_A026020	PGDB_C007553	PGDB_AS001371	View
Ymin	-	=	5.6	%	Concentration context: Y min : (%)	120 h	-	-	MM.1S	EP4393915A1	PGDB_A038386	PGDB_C007553	PGDB_AS002328	View
DC50	-	=	0.102	uM	-	—	SALL4	-	HT-1080	EP4393915A1	PGDB_A044123	PGDB_C007553	PGDB_AS000460	View
Dmax	-	=	59.4	%	Concentration context: HiBiT SALL4: D max (%)	20 h	SALL4	-	HT-1080	EP4393915A1	PGDB_A044329	PGDB_C007553	PGDB_AS001601	View
DC50	-	=	0.102	nM	-	—	IKZF1	-	HT-1080	EP4393915A1	PGDB_A047181	PGDB_C007553	PGDB_AS001343	View
DC50	-	=	0.104	uM	-	—	SALL4	-	HT-1080	EP4393915A1	PGDB_A049902	PGDB_C007553	PGDB_AS000384	View
Dmax	-	=	93.8	%	-	20 h	IKZF1	-	HT-1080	EP4393915A1	PGDB_A054645	PGDB_C007553	PGDB_AS000825	View
IC50	-	=	0.022	nM	-	—	-	-	MM.1S	EP4393915A1	PGDB_A059282	PGDB_C007553	PGDB_AS001514	View
Dmax	-	=	59.5	%	Concentration context: HiBiT SALL4:_D max (%)	20 h	SALL4	-	HT-1080	EP4393915A1	PGDB_A077060	PGDB_C007553	PGDB_AS001879	View
DC50	-	=	0.134	nM	-	—	IKZF1	-	HT-1080	EP4393915A1	PGDB_A077740	PGDB_C007553	PGDB_AS001653	View

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