PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(C[C@H]4CCCC[C@@H]4NC4CCC(F)(F)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C008427

FormulaC26H33F2N3O3

Molecular weight473.564

InChIKeyQDZFZUGIHOOPGR-HWWMDGIVSA-N

Physicochemical properties

Exact mass473.249

RDKit cLogP3.72

TPSA78.5

HBD / HBA2 / 4

Rotatable bonds5

Heavy atoms34

Hetero atoms8

Rings / aromatic5 / 1

Fraction Csp30.65

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	96	%	-	24 h	IKZF2	-	-	JP2026020265A	PGDB_A013638	PGDB_C008427	PGDB_AS002581	View
Dmax	-	=	94	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A015392	PGDB_C008427	PGDB_AS000211	View
Dmax	-	=	95	%	10 uM	overnight	IKZF2	-	Jurkat	JP2026020265A	PGDB_A016183	PGDB_C008427	PGDB_AS002429	View
EC50	-	=	3.5	nM	-	—	IKZF2	-	Jurkat	JP2026020265A	PGDB_A016606	PGDB_C008427	PGDB_AS001603	View
Fold change	DMSO control	=	2.7	fold	10 uM	overnight	IKZF2	-	Jurkat	JP2026020265A	PGDB_A024638	PGDB_C008427	PGDB_AS002326	View
EC50	-	=	0.033	uM	-	—	IKZF1	-	HEK293	JP2026020265A	PGDB_A029483	PGDB_C008427	PGDB_AS002086	View
Dmax	-	=	29	%	-	24 h	IKZF1	-	HEK293	JP2026020265A	PGDB_A031266	PGDB_C008427	PGDB_AS000216	View
EC50	-	=	0.001	uM	-	—	IKZF2	-	HEK293	JP2026020265A	PGDB_A032199	PGDB_C008427	PGDB_AS001535	View
EC50	-	>	10	uM	-	—	SALL4	-	HEK293	JP2026020265A	PGDB_A041180	PGDB_C008427	PGDB_AS001573	View
% Degradation	-	=	0.57	%	-	24 h	IKZF2	-	HEK293	JP2026020265A	PGDB_A043554	PGDB_C008427	PGDB_AS000906	View
EC50	-	=	0.003	uM	-	—	IKZF2	-	-	JP2026020265A	PGDB_A048552	PGDB_C008427	PGDB_AS001524	View
EC50	-	=	2	nM	-	—	IKZF2	-	Jurkat	JP2026020265A	PGDB_A070688	PGDB_C008427	PGDB_AS002391	View

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