PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

N#Cc1ccc(C2CN(Cc3ccc(-c4ccc5c(c4F)CN(C4CCC(=O)NC4=O)C5=O)nc3N)C2)nc1

Compound summary

Compound IDPGDB_C010131

FormulaC28H24FN7O3

Molecular weight525.544

InChIKeySTBPHXSTASSXPE-UHFFFAOYSA-N

Physicochemical properties

Exact mass525.1925

RDKit cLogP2.1

TPSA145.3

HBD / HBA2 / 8

Rotatable bonds5

Heavy atoms39

Hetero atoms11

Rings / aromatic6 / 3

Fraction Csp30.29

Formal charge0

Fragments1

Activity compounds and values

Activity records

26 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
DC50	-	=	32	nM	-	—	IKZF1	-	-	WO2025064197	PGDB_A007528	PGDB_C010131	PGDB_AS000591	View
DC50	-	=	24	nM	-	—	IKZF2	-	Jurkat	WO2025064197	PGDB_A020599	PGDB_C010131	PGDB_AS001529	View
DC50	-	=	15	nM	-	—	IKZF2	-	-	WO2025064197	PGDB_A024456	PGDB_C010131	PGDB_AS001597	View
Dmax	-	=	80	%	-	20 h	IKZF1	-	-	WO2025064197	PGDB_A025339	PGDB_C010131	PGDB_AS001941	View
DC50	-	>	10000	nM	-	—	IKZF3	-	-	WO2025064197	PGDB_A033178	PGDB_C010131	PGDB_AS001891	View
Dmax	-	=	66	%	-	13 d	IKZF2	-	-	WO2025064197	PGDB_A033855	PGDB_C010131	PGDB_AS000562	View
DC50	-	=	30	nM	-	—	IKZF4	-	-	WO2025064197	PGDB_A037354	PGDB_C010131	PGDB_AS001282	View
Dmax	-	=	49	%	-	24 h	IKZF3	-	Jurkat	WO2025064197	PGDB_A037478	PGDB_C010131	PGDB_AS002580	View
DC50	-	=	18	nM	-	—	IKZF2	-	-	WO2025064197	PGDB_A039143	PGDB_C010131	PGDB_AS001515	View
DC50	-	=	135	nM	-	—	IKZF1	-	-	WO2025064197	PGDB_A039353	PGDB_C010131	PGDB_AS002472	View
Dmax	-	=	78	%	-	24 h	IKZF4	-	-	WO2025064197	PGDB_A041418	PGDB_C010131	PGDB_AS001570	View
Dmax	-	=	86	%	-	24 h	IKZF2	-	Jurkat	WO2025064197	PGDB_A042315	PGDB_C010131	PGDB_AS001517	View
Dmax	-	=	82	%	-	24 h	-	-	primary human PBMC	WO2025064197	PGDB_A043803	PGDB_C010131	PGDB_AS001406	View
Dmax	-	=	103	%	-	20 h	IKZF2	-	-	WO2025064197	PGDB_A046205	PGDB_C010131	PGDB_AS001254	View
Dmax	-	=	67	%	-	24 h	IKZF3	-	-	WO2025064197	PGDB_A047645	PGDB_C010131	PGDB_AS000033	View
Dmax	-	=	82	%	-	24 h	IKZF1	-	-	WO2025064197	PGDB_A048014	PGDB_C010131	PGDB_AS002368	View
Dmax	-	=	68	%	-	20 h	IKZF4	-	-	WO2025064197	PGDB_A054862	PGDB_C010131	PGDB_AS001958	View
Dmax	-	=	67	%	-	24 h	-	-	primary human PBMC	WO2025064197	PGDB_A056901	PGDB_C010131	PGDB_AS000355	View
Dmax	-	=	43	%	-	20 h	IKZF3	-	-	WO2025064197	PGDB_A061634	PGDB_C010131	PGDB_AS001828	View
DC50	-	=	230	nM	-	—	IKZF1	-	Jurkat	WO2025064197	PGDB_A063783	PGDB_C010131	PGDB_AS002379	View

Rows per pagePage 1 of 2 · 26 recordsGo to page