PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C=CC(=O)N1C[C@@H]2CCC(c3cc4cc(-c5ccccc5O)nnc4[nH]3)[C@@H]2C1

Compound summary

Compound IDPGDB_C010298

FormulaC22H22N4O2

Molecular weight374.444

InChIKeyZRZVVIYNYWNGNX-BDBMTWCYSA-N

Physicochemical properties

Exact mass374.1743

RDKit cLogP3.47

TPSA82.1

HBD / HBA2 / 4

Rotatable bonds3

Heavy atoms28

Hetero atoms6

Rings / aromatic5 / 3

Fraction Csp30.32

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A007855	PGDB_C010298	PGDB_AS001961	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A010769	PGDB_C010298	PGDB_AS002120	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A012820	PGDB_C010298	PGDB_AS000431	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A024992	PGDB_C010298	PGDB_AS001961	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A038747	PGDB_C010298	PGDB_AS000900	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A039365	PGDB_C010298	PGDB_AS002120	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A043210	PGDB_C010298	PGDB_AS000431	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A045712	PGDB_C010298	PGDB_AS002120	View
DC50	-	<	0.5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A050714	PGDB_C010298	PGDB_AS000431	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A053973	PGDB_C010298	PGDB_AS000900	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A054298	PGDB_C010298	PGDB_AS001961	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A059973	PGDB_C010298	PGDB_AS000900	View

Rows per pagePage 1 of 1 · 12 recordsGo to page