PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2025101944

AssigneePlexium

TitleCompounds and pharmaceutical compositions that degrade swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a

Family ID95696662

Family members2

Filing year2024

Publication date2025-05-15

JurisdictionWO

Compounds457

Activity records2,575

Assays4

Activity compounds and values

Activity records

2,575 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	PGDB_A007016	PGDB_C010524	PGDB_AS001961	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	PGDB_A007028	PGDB_C010683	PGDB_AS000900	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA4	-	HeLa	PGDB_A007031	PGDB_C010540	PGDB_AS002120	View
DC50	-	<	0.5	uM	-	—	SMARCA4	-	HeLa	PGDB_A007044	PGDB_C010699	PGDB_AS000431	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	PGDB_A007047	PGDB_C010341	PGDB_AS000900	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	PGDB_A007057	PGDB_C010349	PGDB_AS000900	View
DC50	-	<	0.5	uM	-	—	SMARCA4	-	HeLa	PGDB_A007076	PGDB_C010669	PGDB_AS000431	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	PGDB_A007141	PGDB_C010505	PGDB_AS002120	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	PGDB_A007144	PGDB_C010598	PGDB_AS000900	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	PGDB_A007175	PGDB_C010563	PGDB_AS000431	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	PGDB_A007184	PGDB_C010778	PGDB_AS000900	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	PGDB_A007198	PGDB_C010647	PGDB_AS001961	View
DC50	-	>	5	uM	-	—	SMARCA4	-	HeLa	PGDB_A007224	PGDB_C010360	PGDB_AS000431	View
DC50	-	<	0.5	uM	-	—	SMARCA4	-	HeLa	PGDB_A007250	PGDB_C010463	PGDB_AS000431	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	PGDB_A007251	PGDB_C010636	PGDB_AS002120	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	PGDB_A007278	PGDB_C010773	PGDB_AS002120	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	PGDB_A007365	PGDB_C010703	PGDB_AS001961	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	PGDB_A007373	PGDB_C010267	PGDB_AS000900	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA4	-	HeLa	PGDB_A007377	PGDB_C010725	PGDB_AS002120	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	PGDB_A007398	PGDB_C010452	PGDB_AS000431	View

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