PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C=CC(=O)N1CC2(CC(c3cc4cc(-c5ccccc5O)nnc4[nH]3)CO2)C1

Compound summary

Compound IDPGDB_C010333

FormulaC21H20N4O3

Molecular weight376.416

InChIKeyKWVQCLMNLZLEGB-UHFFFAOYSA-N

Physicochemical properties

Exact mass376.1535

RDKit cLogP2.6

TPSA91.3

HBD / HBA2 / 5

Rotatable bonds3

Heavy atoms28

Hetero atoms7

Rings / aromatic5 / 3

Fraction Csp30.29

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A008383	PGDB_C010333	PGDB_AS001961	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A012597	PGDB_C010333	PGDB_AS002120	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A013832	PGDB_C010333	PGDB_AS000431	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A015272	PGDB_C010333	PGDB_AS000900	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A029138	PGDB_C010333	PGDB_AS000431	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A042029	PGDB_C010333	PGDB_AS001961	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A042509	PGDB_C010333	PGDB_AS000431	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A047203	PGDB_C010333	PGDB_AS000900	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A049268	PGDB_C010333	PGDB_AS002120	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A058194	PGDB_C010333	PGDB_AS001961	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A062761	PGDB_C010333	PGDB_AS000900	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A063375	PGDB_C010333	PGDB_AS002120	View

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