PatGlueDB | Molecular Glue Patent Bioactivity Database

Loading compound

Loading detail record from the SQLite release...

2D structure

2D structure for PGDB_C010370

C=CC(=O)N1CCCC(c2cc3cc(-c4ccccc4O)nnc3[nH]2)C1

Compound summary

Compound IDPGDB_C010370

FormulaC20H20N4O2

Molecular weight348.406

InChIKeyMMOVFCPIWXMZGR-UHFFFAOYSA-N

Physicochemical properties

Exact mass348.1586

RDKit cLogP3.22

TPSA82.1

HBD / HBA2 / 4

Rotatable bonds3

Heavy atoms26

Hetero atoms6

Rings / aromatic4 / 3

Fraction Csp30.25

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

Structure		Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
	DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A008421	PGDB_C010370	PGDB_AS000900	View
	% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A009707	PGDB_C010370	PGDB_AS001961	View
	% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A014135	PGDB_C010370	PGDB_AS002120	View
	% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A020865	PGDB_C010370	PGDB_AS002120	View
	DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A032024	PGDB_C010370	PGDB_AS000900	View
	DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A037916	PGDB_C010370	PGDB_AS000900	View
	DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A040037	PGDB_C010370	PGDB_AS000431	View
	% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A048866	PGDB_C010370	PGDB_AS002120	View
	% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A070956	PGDB_C010370	PGDB_AS001961	View
	DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A072161	PGDB_C010370	PGDB_AS000431	View
	% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A074790	PGDB_C010370	PGDB_AS001961	View
	DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A077783	PGDB_C010370	PGDB_AS000431	View

Rows per pagePage 1 of 1 · 12 recordsGo to page