PatGlueDB | Molecular Glue Patent Bioactivity Database

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2D structure

2D structure for PGDB_C010389

C=CC(=O)N1CCCCC1c1cc2cc(-c3ccccc3O)nnc2[nH]1

Compound summary

Compound IDPGDB_C010389

FormulaC20H20N4O2

Molecular weight348.406

InChIKeyKFVIJRKMDJSIKP-UHFFFAOYSA-N

Physicochemical properties

Exact mass348.1586

RDKit cLogP3.57

TPSA82.1

HBD / HBA2 / 4

Rotatable bonds3

Heavy atoms26

Hetero atoms6

Rings / aromatic4 / 3

Fraction Csp30.25

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

Structure		Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
	% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A008476	PGDB_C010389	PGDB_AS001961	View
	DC50	-	<	0.5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A010037	PGDB_C010389	PGDB_AS000431	View
	% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A022445	PGDB_C010389	PGDB_AS001961	View
	DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A030055	PGDB_C010389	PGDB_AS000900	View
	DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A034431	PGDB_C010389	PGDB_AS000431	View
	% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A043305	PGDB_C010389	PGDB_AS002120	View
	% Degradation	-	>	70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A052510	PGDB_C010389	PGDB_AS002120	View
	% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A057054	PGDB_C010389	PGDB_AS001961	View
	DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A060288	PGDB_C010389	PGDB_AS000900	View
	DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A062953	PGDB_C010389	PGDB_AS000900	View
	DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A072291	PGDB_C010389	PGDB_AS000431	View
	% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A076286	PGDB_C010389	PGDB_AS002120	View

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