PatGlueDB | Molecular Glue Patent Bioactivity Database

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2D structure

2D structure for PGDB_C010478

C=CC(=O)N1CCOCC1c1[nH]c2nnc(-c3ccccc3O)cc2c1Br

Compound summary

Compound IDPGDB_C010478

FormulaC19H17BrN4O3

Molecular weight429.274

InChIKeyFIPILAUTFVLUNS-UHFFFAOYSA-N

Physicochemical properties

Exact mass428.0484

RDKit cLogP3.18

TPSA91.3

HBD / HBA2 / 5

Rotatable bonds3

Heavy atoms27

Hetero atoms8

Rings / aromatic4 / 3

Fraction Csp30.21

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

Structure		Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
	% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A007666	PGDB_C010478	PGDB_AS001961	View
	DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A008615	PGDB_C010478	PGDB_AS000900	View
	% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A008828	PGDB_C010478	PGDB_AS002120	View
	% Degradation	-	>	70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A017964	PGDB_C010478	PGDB_AS002120	View
	DC50	-	<	0.5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A027089	PGDB_C010478	PGDB_AS000431	View
	% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A032412	PGDB_C010478	PGDB_AS002120	View
	DC50	-	<	0.5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A043085	PGDB_C010478	PGDB_AS000431	View
	DC50	-	<	0.5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A053082	PGDB_C010478	PGDB_AS000431	View
	DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A053600	PGDB_C010478	PGDB_AS000900	View
	% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A056971	PGDB_C010478	PGDB_AS001961	View
	DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A062991	PGDB_C010478	PGDB_AS000900	View
	% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A067750	PGDB_C010478	PGDB_AS001961	View

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