PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C=CC(=O)N1CC2(C1)OCCC2c1cc2cc(-c3ccccc3O)nnc2[nH]1

Compound summary

Compound IDPGDB_C010486

FormulaC21H20N4O3

Molecular weight376.416

InChIKeyKHYVUUJLNLAFRU-UHFFFAOYSA-N

Physicochemical properties

Exact mass376.1535

RDKit cLogP2.6

TPSA91.3

HBD / HBA2 / 5

Rotatable bonds3

Heavy atoms28

Hetero atoms7

Rings / aromatic5 / 3

Fraction Csp30.29

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A009606	PGDB_C010486	PGDB_AS002120	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A014159	PGDB_C010486	PGDB_AS002120	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A020342	PGDB_C010486	PGDB_AS000431	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A022331	PGDB_C010486	PGDB_AS000900	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A030388	PGDB_C010486	PGDB_AS000431	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A033332	PGDB_C010486	PGDB_AS000900	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A038638	PGDB_C010486	PGDB_AS001961	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A040365	PGDB_C010486	PGDB_AS002120	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A047739	PGDB_C010486	PGDB_AS000900	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A055139	PGDB_C010486	PGDB_AS001961	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A062352	PGDB_C010486	PGDB_AS001961	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A074460	PGDB_C010486	PGDB_AS000431	View

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