PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C=CC(=O)N1CCC1Cc1[nH]c2nnc(-c3ccccc3O)cc2c1C1CC1

Compound summary

Compound IDPGDB_C010496

FormulaC22H22N4O2

Molecular weight374.444

InChIKeyULXLQMTWPLCRHJ-UHFFFAOYSA-N

Physicochemical properties

Exact mass374.1743

RDKit cLogP3.54

TPSA82.1

HBD / HBA2 / 4

Rotatable bonds5

Heavy atoms28

Hetero atoms6

Rings / aromatic5 / 3

Fraction Csp30.32

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A009601	PGDB_C010496	PGDB_AS001961	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A018977	PGDB_C010496	PGDB_AS000900	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A038967	PGDB_C010496	PGDB_AS000431	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A042042	PGDB_C010496	PGDB_AS000900	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A042145	PGDB_C010496	PGDB_AS002120	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A042385	PGDB_C010496	PGDB_AS002120	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A058493	PGDB_C010496	PGDB_AS001961	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A059035	PGDB_C010496	PGDB_AS000900	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A059569	PGDB_C010496	PGDB_AS002120	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A063101	PGDB_C010496	PGDB_AS000431	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A063644	PGDB_C010496	PGDB_AS000431	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A067093	PGDB_C010496	PGDB_AS001961	View

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