PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C=CC(=O)N1CC(c2cc3cc(-c4ccccc4O)nnc3[nH]2)C[C@@H]1C(=O)N(C)C

Compound summary

Compound IDPGDB_C010510

FormulaC22H23N5O3

Molecular weight405.458

InChIKeyQDUKKQQRTFKWFT-XPKAQORNSA-N

Physicochemical properties

Exact mass405.1801

RDKit cLogP2.29

TPSA102.4

HBD / HBA2 / 5

Rotatable bonds4

Heavy atoms30

Hetero atoms8

Rings / aromatic4 / 3

Fraction Csp30.27

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A007689	PGDB_C010510	PGDB_AS000431	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A019987	PGDB_C010510	PGDB_AS000900	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A024766	PGDB_C010510	PGDB_AS002120	View
DC50	-	>	5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A029608	PGDB_C010510	PGDB_AS000431	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A032549	PGDB_C010510	PGDB_AS001961	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A037245	PGDB_C010510	PGDB_AS001961	View
DC50	-	>	5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A038136	PGDB_C010510	PGDB_AS000431	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A039724	PGDB_C010510	PGDB_AS001961	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A040124	PGDB_C010510	PGDB_AS002120	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A057993	PGDB_C010510	PGDB_AS000900	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A065801	PGDB_C010510	PGDB_AS000900	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A074203	PGDB_C010510	PGDB_AS002120	View

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