PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C=CC(=O)N1CCC1Cc1[nH]c2nnc(-c3ccccc3O)cc2c1C(C)C

Compound summary

Compound IDPGDB_C010540

FormulaC22H24N4O2

Molecular weight376.46

InChIKeyIMZLFMFIDIBXQL-UHFFFAOYSA-N

Physicochemical properties

Exact mass376.1899

RDKit cLogP3.78

TPSA82.1

HBD / HBA2 / 4

Rotatable bonds5

Heavy atoms28

Hetero atoms6

Rings / aromatic4 / 3

Fraction Csp30.32

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>	70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A007031	PGDB_C010540	PGDB_AS002120	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A008643	PGDB_C010540	PGDB_AS000900	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A014083	PGDB_C010540	PGDB_AS002120	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A016487	PGDB_C010540	PGDB_AS002120	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A016745	PGDB_C010540	PGDB_AS001961	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A018022	PGDB_C010540	PGDB_AS000900	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A020223	PGDB_C010540	PGDB_AS000431	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A022457	PGDB_C010540	PGDB_AS001961	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A037897	PGDB_C010540	PGDB_AS001961	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A041559	PGDB_C010540	PGDB_AS000900	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A051880	PGDB_C010540	PGDB_AS000431	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A068569	PGDB_C010540	PGDB_AS000431	View

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