PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C=CC(=O)N1CC(c2cc3cc(-c4ccccc4O)nnc3[nH]2)CC1COC

Compound summary

Compound IDPGDB_C010598

FormulaC21H22N4O3

Molecular weight378.432

InChIKeyGCDQGYVVOVSLNJ-UHFFFAOYSA-N

Physicochemical properties

Exact mass378.1692

RDKit cLogP2.85

TPSA91.3

HBD / HBA2 / 5

Rotatable bonds5

Heavy atoms28

Hetero atoms7

Rings / aromatic4 / 3

Fraction Csp30.29

Formal charge0

Fragments1

Activity compounds and values

Activity records

16 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A007144	PGDB_C010598	PGDB_AS000900	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A012018	PGDB_C010598	PGDB_AS002120	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A025845	PGDB_C010598	PGDB_AS000431	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A027009	PGDB_C010598	PGDB_AS002120	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A032927	PGDB_C010598	PGDB_AS001961	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A034661	PGDB_C010598	PGDB_AS000900	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A036783	PGDB_C010598	PGDB_AS000431	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A038875	PGDB_C010598	PGDB_AS001961	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A045154	PGDB_C010598	PGDB_AS002120	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A048274	PGDB_C010598	PGDB_AS000431	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A053554	PGDB_C010598	PGDB_AS001961	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A059121	PGDB_C010598	PGDB_AS000900	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A063738	PGDB_C010598	PGDB_AS002120	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A069191	PGDB_C010598	PGDB_AS000431	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A074526	PGDB_C010598	PGDB_AS001961	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A077355	PGDB_C010598	PGDB_AS000900	View

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