PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C=CC(=O)N1CC(c2[nH]c3nnc(-c4ccccc4O)cc3c2C2CCOC2)[C@H](OC)C1

Compound summary

Compound IDPGDB_C010634

FormulaC24H26N4O4

Molecular weight434.496

InChIKeySWKAMCGVFVFFKZ-CODVMQSSSA-N

Physicochemical properties

Exact mass434.1954

RDKit cLogP2.96

TPSA100.6

HBD / HBA2 / 6

Rotatable bonds5

Heavy atoms32

Hetero atoms8

Rings / aromatic5 / 3

Fraction Csp30.38

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A007674	PGDB_C010634	PGDB_AS000900	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A015348	PGDB_C010634	PGDB_AS002120	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A017566	PGDB_C010634	PGDB_AS002120	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A024200	PGDB_C010634	PGDB_AS001961	View
DC50	-	<	0.5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A024738	PGDB_C010634	PGDB_AS000431	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A033123	PGDB_C010634	PGDB_AS001961	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A037470	PGDB_C010634	PGDB_AS000900	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A040438	PGDB_C010634	PGDB_AS000431	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A053598	PGDB_C010634	PGDB_AS000900	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A055520	PGDB_C010634	PGDB_AS001961	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A055792	PGDB_C010634	PGDB_AS002120	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A069379	PGDB_C010634	PGDB_AS000431	View

Rows per pagePage 1 of 1 · 12 recordsGo to page