PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C=CC(=O)N1CC2CCC(c3[nH]c4nnc(-c5ccccc5O)cc4c3C3CCOC3)C21

Compound summary

Compound IDPGDB_C010653

FormulaC25H26N4O3

Molecular weight430.508

InChIKeyXAQIOBFGJILSCV-UHFFFAOYSA-N

Physicochemical properties

Exact mass430.2005

RDKit cLogP3.72

TPSA91.3

HBD / HBA2 / 5

Rotatable bonds4

Heavy atoms32

Hetero atoms7

Rings / aromatic6 / 3

Fraction Csp30.4

Formal charge0

Fragments1

Activity compounds and values

Activity records

16 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>	70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A008627	PGDB_C010653	PGDB_AS002120	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A008677	PGDB_C010653	PGDB_AS001961	View
DC50	-	<	0.5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A011691	PGDB_C010653	PGDB_AS000431	View
DC50	-	<	0.5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A012230	PGDB_C010653	PGDB_AS000431	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A017723	PGDB_C010653	PGDB_AS001961	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A020606	PGDB_C010653	PGDB_AS001961	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A028487	PGDB_C010653	PGDB_AS000900	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A035823	PGDB_C010653	PGDB_AS002120	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A041896	PGDB_C010653	PGDB_AS000431	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A046913	PGDB_C010653	PGDB_AS001961	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A048663	PGDB_C010653	PGDB_AS000900	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A059620	PGDB_C010653	PGDB_AS002120	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A065229	PGDB_C010653	PGDB_AS000900	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A068315	PGDB_C010653	PGDB_AS002120	View
DC50	-	<	0.5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A074671	PGDB_C010653	PGDB_AS000431	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A077114	PGDB_C010653	PGDB_AS000900	View

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