PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C=CC(=O)N1CC2(CCC2c2[nH]c3nnc(-c4cccc(F)c4O)cc3c2C)C1

Compound summary

Compound IDPGDB_C010725

FormulaC22H21FN4O2

Molecular weight392.434

InChIKeyLGPBSMYPFQWRMK-UHFFFAOYSA-N

Physicochemical properties

Exact mass392.1649

RDKit cLogP3.67

TPSA82.1

HBD / HBA2 / 4

Rotatable bonds3

Heavy atoms29

Hetero atoms7

Rings / aromatic5 / 3

Fraction Csp30.32

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>	70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A007377	PGDB_C010725	PGDB_AS002120	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A008566	PGDB_C010725	PGDB_AS000900	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A010969	PGDB_C010725	PGDB_AS001961	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A012452	PGDB_C010725	PGDB_AS000431	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A017109	PGDB_C010725	PGDB_AS000900	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A019788	PGDB_C010725	PGDB_AS000900	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A026718	PGDB_C010725	PGDB_AS001961	View
DC50	-	<	0.5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A030100	PGDB_C010725	PGDB_AS000431	View
DC50	-	<	0.5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A046543	PGDB_C010725	PGDB_AS000431	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A058323	PGDB_C010725	PGDB_AS001961	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A058972	PGDB_C010725	PGDB_AS002120	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A075149	PGDB_C010725	PGDB_AS002120	View

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