PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C=CC(=O)N1[C@@H]2COC[C@H]1C[C@H](c1[nH]c3nnc(-c4ccccc4O)cc3c1C1CCCCO1)C2

Compound summary

Compound IDPGDB_C010809

FormulaC27H30N4O4

Molecular weight474.561

InChIKeyDFRVXNGMQLDHRJ-XHICYHHKSA-N

Physicochemical properties

Exact mass474.2267

RDKit cLogP4.23

TPSA100.6

HBD / HBA2 / 6

Rotatable bonds4

Heavy atoms35

Hetero atoms8

Rings / aromatic6 / 3

Fraction Csp30.44

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A008452	PGDB_C010809	PGDB_AS000900	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A011956	PGDB_C010809	PGDB_AS002120	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A015254	PGDB_C010809	PGDB_AS001961	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A018974	PGDB_C010809	PGDB_AS001961	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A032465	PGDB_C010809	PGDB_AS002120	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A036514	PGDB_C010809	PGDB_AS000900	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A049921	PGDB_C010809	PGDB_AS000431	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A054730	PGDB_C010809	PGDB_AS000431	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A058113	PGDB_C010809	PGDB_AS001961	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A058720	PGDB_C010809	PGDB_AS002120	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A070099	PGDB_C010809	PGDB_AS000900	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A072659	PGDB_C010809	PGDB_AS000431	View

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