PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C=CC(=O)N1C2COCC1CC(c1[nH]c3nnc(-c4ccccc4O)cc3c1CCOC1CCOC1)C2

Compound summary

Compound IDPGDB_C010820

FormulaC28H32N4O5

Molecular weight504.587

InChIKeyPKHWWZJQLYWETH-UHFFFAOYSA-N

Physicochemical properties

Exact mass504.2373

RDKit cLogP3.34

TPSA109.8

HBD / HBA2 / 7

Rotatable bonds7

Heavy atoms37

Hetero atoms9

Rings / aromatic6 / 3

Fraction Csp30.46

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A009332	PGDB_C010820	PGDB_AS001961	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A017784	PGDB_C010820	PGDB_AS001961	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A018211	PGDB_C010820	PGDB_AS002120	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A035317	PGDB_C010820	PGDB_AS000900	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A039370	PGDB_C010820	PGDB_AS002120	View
DC50	-	<	0.5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A044249	PGDB_C010820	PGDB_AS000431	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A045524	PGDB_C010820	PGDB_AS000431	View
% Degradation	-	>	70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A050000	PGDB_C010820	PGDB_AS002120	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A061949	PGDB_C010820	PGDB_AS001961	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A063510	PGDB_C010820	PGDB_AS000900	View
DC50	-	>	5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A067329	PGDB_C010820	PGDB_AS000431	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A076178	PGDB_C010820	PGDB_AS000900	View

Rows per pagePage 1 of 1 · 12 recordsGo to page