PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CN(C)C/C=C/C(=O)N1CC[C@@H](c2[nH]c3nnc(-c4ccccc4O)cc3c2C2CCCO2)C1

Compound summary

Compound IDPGDB_C010841

FormulaC26H31N5O3

Molecular weight461.566

InChIKeyZZOUZCGTJLJNIZ-PCEWSRPPSA-N

Physicochemical properties

Exact mass461.2427

RDKit cLogP3.62

TPSA94.6

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms34

Hetero atoms8

Rings / aromatic5 / 3

Fraction Csp30.42

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
DC50	-	>	5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A008867	PGDB_C010841	PGDB_AS000431	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A018775	PGDB_C010841	PGDB_AS002120	View
DC50	-	>	5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A032709	PGDB_C010841	PGDB_AS000431	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A033349	PGDB_C010841	PGDB_AS001961	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A035291	PGDB_C010841	PGDB_AS002120	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A037340	PGDB_C010841	PGDB_AS000900	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A039480	PGDB_C010841	PGDB_AS000900	View
% Degradation	-	<	30	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A047000	PGDB_C010841	PGDB_AS002120	View
DC50	-	>	5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A052047	PGDB_C010841	PGDB_AS000431	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A067067	PGDB_C010841	PGDB_AS001961	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A069244	PGDB_C010841	PGDB_AS001961	View
DC50	-	=	0.5-5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A070048	PGDB_C010841	PGDB_AS000900	View

Rows per pagePage 1 of 1 · 12 recordsGo to page