PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CN1CCN(c2cc(NCc3nc4ccc(F)c(F)c4[nH]3)c3ncc(C(F)(F)F)n3n2)CC1

Compound summary

Compound IDPGDB_C010902

FormulaC20H19F5N8

Molecular weight466.418

InChIKeyZOYLBOHFLOGWIB-UHFFFAOYSA-N

Physicochemical properties

Exact mass466.1653

RDKit cLogP3.27

TPSA77.4

HBD / HBA2 / 7

Rotatable bonds4

Heavy atoms33

Hetero atoms13

Rings / aromatic5 / 4

Fraction Csp30.35

Formal charge0

Fragments1

Activity compounds and values

Activity records

32 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	<=	0.2	uM	-	—	-	-	SW480	WO2025110815A1	PGDB_A009579	PGDB_C010902	PGDB_AS002136	View
IC50	-	<=	0.2	uM	-	—	-	-	SNU-1	WO2025110815A1	PGDB_A011751	PGDB_C010902	PGDB_AS001364	View
IC50	-	<=	0.05	uM	-	—	-	-	BT-20	WO2025110815A1	PGDB_A013997	PGDB_C010902	PGDB_AS000821	View
IC50	-	<=	0.2	uM	-	—	-	-	AsPC-1	WO2025110815A1	PGDB_A016336	PGDB_C010902	PGDB_AS002068	View
IC50	-	<=	0.2	uM	-	—	-	-	AGS	WO2025110815A1	PGDB_A019006	PGDB_C010902	PGDB_AS000706	View
IC50	-	<=	0.2	uM	-	—	-	-	HT-29	WO2025110815A1	PGDB_A019027	PGDB_C010902	PGDB_AS000483	View
IC50	-	<=	0.2	uM	-	—	-	-	MKN45	WO2025110815A1	PGDB_A022430	PGDB_C010902	PGDB_AS000058	View
IC50	-	<=	0.2	uM	-	—	-	-	AGS	WO2025110815A1	PGDB_A024134	PGDB_C010902	PGDB_AS000697	View
IC50	-	<=	0.3	uM	-	—	POLR2A	-	-	WO2025110815A1	PGDB_A024773	PGDB_C010902	PGDB_AS000589	View
IC50	-	<=	0.05	uM	-	—	-	-	MDA-MB-436	WO2025110815A1	PGDB_A026830	PGDB_C010902	PGDB_AS002448	View
IC50	-	<=	0.2	uM	-	—	-	-	KATO-III	WO2025110815A1	PGDB_A031255	PGDB_C010902	PGDB_AS001579	View
IC50	-	<=	0.2	uM	-	—	-	-	A-427	WO2025110815A1	PGDB_A036234	PGDB_C010902	PGDB_AS000633	View
IC50	-	<=	0.2	uM	-	—	-	-	SNU601	WO2025110815A1	PGDB_A037567	PGDB_C010902	PGDB_AS001239	View
IC50	-	<=	0.1	uM	-	—	CDK12	-	-	WO2025110815A1	PGDB_A040080	PGDB_C010902	PGDB_AS002095	View
IC50	-	<=	0.2	uM	-	—	-	-	NCI-N87	WO2025110815A1	PGDB_A042928	PGDB_C010902	PGDB_AS001693	View
IC50	-	<=	0.2	uM	-	—	-	-	SW620	WO2025110815A1	PGDB_A045218	PGDB_C010902	PGDB_AS001109	View
IC50	-	<=	0.2	uM	-	—	-	-	LoVo	WO2025110815A1	PGDB_A046185	PGDB_C010902	PGDB_AS001938	View
IC50	-	<=	0.2	uM	-	—	-	-	HCT15	WO2025110815A1	PGDB_A046437	PGDB_C010902	PGDB_AS001666	View
IC50	-	<=	0.05	uM	-	—	-	-	HCC70	WO2025110815A1	PGDB_A046509	PGDB_C010902	PGDB_AS001231	View
IC50	-	<=	0.2	uM	-	—	-	-	NCI-H358	WO2025110815A1	PGDB_A051616	PGDB_C010902	PGDB_AS000696	View

Rows per pagePage 1 of 2 · 32 recordsGo to page