PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2025110815A1

AssigneeIleadbms

TitleImidazo [1,2-b] pyridazine-based novel compound as cdk inhibitor and use thereof

Family ID95827079

Family members1

Filing year2024

Publication date2025-05-30

JurisdictionWO

Compounds109

Activity records545

Assays32

Activity compounds and values

Activity records

545 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	<=	0.1	uM	-	—	CDK13	-	-	PGDB_A007078	PGDB_C010919	PGDB_AS001146	View
IC50	-	<=	0.3	uM	-	—	POLR2A	-	-	PGDB_A007136	PGDB_C010990	PGDB_AS000589	View
IC50	-	=	0.05-0.5	uM	-	—	-	-	MDA-MB-231	PGDB_A007260	PGDB_C010931	PGDB_AS000344	View
IC50	-	>	0.5	uM	-	—	-	-	MDA-MB-231	PGDB_A007382	PGDB_C010927	PGDB_AS000344	View
IC50	-	<=	0.1	uM	-	—	CDK13	-	-	PGDB_A007659	PGDB_C010967	PGDB_AS001146	View
IC50	-	<=	0.1	uM	-	—	CDK12	-	-	PGDB_A007735	PGDB_C010941	PGDB_AS002095	View
Selectivity index	CDK1 / CDK12	=	100-500	fold	-	—	-	-	-	PGDB_A007998	PGDB_C010952	PGDB_AS002417	View
IC50	-	=	0.1-0.5	uM	-	—	CDK13	-	-	PGDB_A008213	PGDB_C010923	PGDB_AS001146	View
IC50	-	<=	0.05	uM	-	—	-	-	MDA-MB-231	PGDB_A008242	PGDB_C010982	PGDB_AS000344	View
IC50	-	=	0.3-3	uM	-	—	POLR2A	-	-	PGDB_A008267	PGDB_C010965	PGDB_AS000589	View
IC50	-	<=	0.3	uM	-	—	POLR2A	-	-	PGDB_A008324	PGDB_C011002	PGDB_AS000589	View
Selectivity index	CDK1 / CDK12	>	500	fold	-	—	-	-	-	PGDB_A008572	PGDB_C010960	PGDB_AS002417	View
Selectivity index	CDK1 / CDK12	>	500	fold	-	—	-	-	-	PGDB_A008916	PGDB_C010920	PGDB_AS002417	View
IC50	-	<=	0.2	uM	-	—	-	-	MKN1	PGDB_A008972	PGDB_C010943	PGDB_AS000785	View
IC50	-	>	0.5	uM	-	—	-	-	MDA-MB-231	PGDB_A009022	PGDB_C010924	PGDB_AS000344	View
IC50	-	<=	0.3	uM	-	—	POLR2A	-	-	PGDB_A009103	PGDB_C010921	PGDB_AS000589	View
IC50	-	<=	0.3	uM	-	—	POLR2A	-	-	PGDB_A009351	PGDB_C011000	PGDB_AS000589	View
IC50	-	<=	0.2	uM	-	—	-	-	SW480	PGDB_A009579	PGDB_C010902	PGDB_AS002136	View
IC50	-	<=	0.1	uM	-	—	CDK13	-	-	PGDB_A009848	PGDB_C010977	PGDB_AS001146	View
IC50	-	>	3	uM	-	—	POLR2A	-	-	PGDB_A009975	PGDB_C010929	PGDB_AS000589	View

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