PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3ccc(CN4CCN(c5ccc(Cl)c(Cl)c5)CC4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019424

FormulaC24H22Cl2N4O4

Molecular weight501.37

InChIKeyJMMPDGDLNTYASD-UHFFFAOYSA-N

Physicochemical properties

Exact mass500.1018

RDKit cLogP2.72

TPSA90

HBD / HBA1 / 6

Rotatable bonds4

Heavy atoms34

Hetero atoms10

Rings / aromatic5 / 2

Fraction Csp30.33

Formal charge0

Fragments1

Activity compounds and values

Activity records

6 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A007264	PGDB_C019424	PGDB_AS001647	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A020970	PGDB_C019424	PGDB_AS002547	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A038050	PGDB_C019424	PGDB_AS001760	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A038650	PGDB_C019424	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A040986	PGDB_C019424	PGDB_AS000700	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A051229	PGDB_C019424	PGDB_AS000593	View

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