PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1nc(C2CCN(Cc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)c2c3c(sc2n1)CCCC3

Compound summary

Compound IDPGDB_C019459

FormulaC30H31N5O4S

Molecular weight557.676

InChIKeyFIHWGVNMDNTHPR-UHFFFAOYSA-N

Physicochemical properties

Exact mass557.2097

RDKit cLogP3.66

TPSA112.6

HBD / HBA1 / 8

Rotatable bonds4

Heavy atoms40

Hetero atoms10

Rings / aromatic7 / 3

Fraction Csp30.47

Formal charge0

Fragments1

Activity compounds and values

Activity records

6 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A008611	PGDB_C019459	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A022333	PGDB_C019459	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A049612	PGDB_C019459	PGDB_AS002547	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A063036	PGDB_C019459	PGDB_AS002465	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A068836	PGDB_C019459	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A077245	PGDB_C019459	PGDB_AS001647	View

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