PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1nc(C2=CCN(Cc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)c2ccsc2n1

Compound summary

Compound IDPGDB_C019472

FormulaC26H23N5O4S

Molecular weight501.568

InChIKeyKUNSQYKSRDTMNW-UHFFFAOYSA-N

Physicochemical properties

Exact mass501.1471

RDKit cLogP2.69

TPSA112.6

HBD / HBA1 / 8

Rotatable bonds4

Heavy atoms36

Hetero atoms10

Rings / aromatic6 / 3

Fraction Csp30.31

Formal charge0

Fragments1

Activity compounds and values

Activity records

9 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A023550	PGDB_C019472	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A025801	PGDB_C019472	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A027021	PGDB_C019472	PGDB_AS000700	View
IC50	-	=	100-500	nM	-	—	-	-	MOLT-4	WO2025016359A1	PGDB_A046988	PGDB_C019472	PGDB_AS000277	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A047573	PGDB_C019472	PGDB_AS002465	View
IC50	-	=	100-500	nM	-	—	-	-	CCRF-CEM	WO2025016359A1	PGDB_A050964	PGDB_C019472	PGDB_AS001127	View
IC50	-	=	100-500	nM	-	—	-	-	MV-4-11	WO2025016359A1	PGDB_A059546	PGDB_C019472	PGDB_AS001504	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A066867	PGDB_C019472	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A066989	PGDB_C019472	PGDB_AS001760	View

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