PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1ccc(Sc2ccccc2N2CCN(Cc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)c(C)c1

Compound summary

Compound IDPGDB_C019476

FormulaC32H32N4O4S

Molecular weight568.699

InChIKeyWAVSTSDKGYKUGG-UHFFFAOYSA-N

Physicochemical properties

Exact mass568.2144

RDKit cLogP4.18

TPSA90

HBD / HBA1 / 7

Rotatable bonds6

Heavy atoms41

Hetero atoms9

Rings / aromatic6 / 3

Fraction Csp30.31

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	10-50	nM	-	—	-	-	MV-4-11	WO2025016359A1	PGDB_A024863	PGDB_C019476	PGDB_AS001504	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A027182	PGDB_C019476	PGDB_AS002547	View
IC50	-	=	100-500	nM	-	—	-	-	MOLT-4	WO2025016359A1	PGDB_A037882	PGDB_C019476	PGDB_AS000277	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A040601	PGDB_C019476	PGDB_AS000700	View
IC50	-	=	100-500	nM	-	—	-	-	CCRF-CEM	WO2025016359A1	PGDB_A051181	PGDB_C019476	PGDB_AS001127	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A052202	PGDB_C019476	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A052736	PGDB_C019476	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A056494	PGDB_C019476	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A056988	PGDB_C019476	PGDB_AS001647	View
IC50	-	=	100-500	nM	-	—	-	-	MM.1S	WO2025016359A1	PGDB_A075710	PGDB_C019476	PGDB_AS001138	View

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