PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3ccc(CN4CCC(c5c[nH]c6cc(F)ccc56)CC4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019491

FormulaC27H25FN4O4

Molecular weight488.519

InChIKeySHSYJBSDLRWIHH-UHFFFAOYSA-N

Physicochemical properties

Exact mass488.186

RDKit cLogP3.09

TPSA102.6

HBD / HBA2 / 5

Rotatable bonds4

Heavy atoms36

Hetero atoms9

Rings / aromatic6 / 3

Fraction Csp30.33

Formal charge0

Fragments1

Activity compounds and values

Activity records

11 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A007715	PGDB_C019491	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A021633	PGDB_C019491	PGDB_AS001647	View
IC50	-	=	50-100	nM	-	—	-	-	MV-4-11	WO2025016359A1	PGDB_A027980	PGDB_C019491	PGDB_AS001504	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A044657	PGDB_C019491	PGDB_AS001760	View
IC50	-	=	100-500	nM	-	—	-	-	Jurkat	WO2025016359A1	PGDB_A047708	PGDB_C019491	PGDB_AS002351	View
IC50	-	=	100-500	nM	-	—	-	-	MM.1S	WO2025016359A1	PGDB_A053241	PGDB_C019491	PGDB_AS001138	View
IC50	-	=	100-500	nM	-	—	-	-	MOLT-4	WO2025016359A1	PGDB_A058408	PGDB_C019491	PGDB_AS000277	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A060332	PGDB_C019491	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A068330	PGDB_C019491	PGDB_AS000700	View
IC50	-	=	100-500	nM	-	—	-	-	CCRF-CEM	WO2025016359A1	PGDB_A071463	PGDB_C019491	PGDB_AS001127	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A073779	PGDB_C019491	PGDB_AS000593	View

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