PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3ccc(CN4CC=C(c5c[nH]c6ncccc56)CC4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019496

FormulaC26H23N5O4

Molecular weight469.501

InChIKeyZHBKDGMVZZSIBK-UHFFFAOYSA-N

Physicochemical properties

Exact mass469.175

RDKit cLogP2.25

TPSA115.5

HBD / HBA2 / 6

Rotatable bonds4

Heavy atoms35

Hetero atoms9

Rings / aromatic6 / 3

Fraction Csp30.27

Formal charge0

Fragments1

Activity compounds and values

Activity records

9 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A022240	PGDB_C019496	PGDB_AS001760	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A028570	PGDB_C019496	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A030403	PGDB_C019496	PGDB_AS000593	View
IC50	-	=	500-1000	nM	-	—	-	-	MOLT-4	WO2025016359A1	PGDB_A043164	PGDB_C019496	PGDB_AS000277	View
IC50	-	=	500-1000	nM	-	—	-	-	CCRF-CEM	WO2025016359A1	PGDB_A055026	PGDB_C019496	PGDB_AS001127	View
IC50	-	=	100-500	nM	-	—	-	-	MV-4-11	WO2025016359A1	PGDB_A055225	PGDB_C019496	PGDB_AS001504	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A056621	PGDB_C019496	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A059767	PGDB_C019496	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A075779	PGDB_C019496	PGDB_AS002547	View

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