PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3ccc(CN4CCN(c5c[nH]c6ncccc56)CC4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019497

FormulaC25H24N6O4

Molecular weight472.505

InChIKeyMQZGVFOCTIRTSJ-UHFFFAOYSA-N

Physicochemical properties

Exact mass472.1859

RDKit cLogP1.29

TPSA118.7

HBD / HBA2 / 7

Rotatable bonds4

Heavy atoms35

Hetero atoms10

Rings / aromatic6 / 3

Fraction Csp30.32

Formal charge0

Fragments1

Activity compounds and values

Activity records

6 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A009256	PGDB_C019497	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A021625	PGDB_C019497	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A035436	PGDB_C019497	PGDB_AS001647	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A046069	PGDB_C019497	PGDB_AS001760	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A049160	PGDB_C019497	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A057571	PGDB_C019497	PGDB_AS000700	View

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