PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3ccc(CN4CC=C(c5cncc(Cl)c5)CC4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019508

FormulaC24H21ClN4O4

Molecular weight464.909

InChIKeyBYDMFSDYCMFGRL-UHFFFAOYSA-N

Physicochemical properties

Exact mass464.1251

RDKit cLogP2.43

TPSA99.7

HBD / HBA1 / 6

Rotatable bonds4

Heavy atoms33

Hetero atoms9

Rings / aromatic5 / 2

Fraction Csp30.29

Formal charge0

Fragments1

Activity compounds and values

Activity records

9 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A009885	PGDB_C019508	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A015935	PGDB_C019508	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A027892	PGDB_C019508	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A040655	PGDB_C019508	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A044190	PGDB_C019508	PGDB_AS001760	View
IC50	-	=	100-500	nM	-	—	-	-	MV-4-11	WO2025016359A1	PGDB_A045034	PGDB_C019508	PGDB_AS001504	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A050818	PGDB_C019508	PGDB_AS002465	View
IC50	-	=	500-1000	nM	-	—	-	-	MOLT-4	WO2025016359A1	PGDB_A052030	PGDB_C019508	PGDB_AS000277	View
IC50	-	=	100-500	nM	-	—	-	-	CCRF-CEM	WO2025016359A1	PGDB_A069832	PGDB_C019508	PGDB_AS001127	View

Rows per pagePage 1 of 1 · 9 recordsGo to page