PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3ccc(CN4CC=C(c5ncccc5F)CC4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019509

FormulaC24H21FN4O4

Molecular weight448.454

InChIKeyQTDSLMHCPMCODE-UHFFFAOYSA-N

Physicochemical properties

Exact mass448.1547

RDKit cLogP1.91

TPSA99.7

HBD / HBA1 / 6

Rotatable bonds4

Heavy atoms33

Hetero atoms9

Rings / aromatic5 / 2

Fraction Csp30.29

Formal charge0

Fragments1

Activity compounds and values

Activity records

9 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A018903	PGDB_C019509	PGDB_AS001647	View
IC50	-	=	500-1000	nM	-	—	-	-	MV-4-11	WO2025016359A1	PGDB_A023454	PGDB_C019509	PGDB_AS001504	View
IC50	-	=	500-1000	nM	-	—	-	-	CCRF-CEM	WO2025016359A1	PGDB_A025409	PGDB_C019509	PGDB_AS001127	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A034163	PGDB_C019509	PGDB_AS002465	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A035989	PGDB_C019509	PGDB_AS000700	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A036261	PGDB_C019509	PGDB_AS001760	View
IC50	-	=	500-1000	nM	-	—	-	-	MOLT-4	WO2025016359A1	PGDB_A047445	PGDB_C019509	PGDB_AS000277	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A062561	PGDB_C019509	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A067967	PGDB_C019509	PGDB_AS002547	View

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