PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3ccc(CN4CC=C(c5ccnc(F)c5F)CC4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019511

FormulaC24H20F2N4O4

Molecular weight466.444

InChIKeyQQXIOMYJEBVLDB-UHFFFAOYSA-N

Physicochemical properties

Exact mass466.1453

RDKit cLogP2.05

TPSA99.7

HBD / HBA1 / 6

Rotatable bonds4

Heavy atoms34

Hetero atoms10

Rings / aromatic5 / 2

Fraction Csp30.29

Formal charge0

Fragments1

Activity compounds and values

Activity records

7 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	10-50	nM	-	—	-	-	MV-4-11	WO2025016359A1	PGDB_A011898	PGDB_C019511	PGDB_AS001504	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A017489	PGDB_C019511	PGDB_AS002465	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A041794	PGDB_C019511	PGDB_AS002547	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A057469	PGDB_C019511	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A060887	PGDB_C019511	PGDB_AS000700	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A061882	PGDB_C019511	PGDB_AS000593	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A067456	PGDB_C019511	PGDB_AS001760	View

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