PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3ccc(CN4CCN(c5nc(N6CCC6)nc6c5SCC6)CC4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019526

FormulaC27H29N7O4S

Molecular weight547.641

InChIKeyHDRIYHVMNJBMDE-UHFFFAOYSA-N

Physicochemical properties

Exact mass547.2002

RDKit cLogP1.06

TPSA119

HBD / HBA1 / 10

Rotatable bonds5

Heavy atoms39

Hetero atoms12

Rings / aromatic7 / 2

Fraction Csp30.48

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2025016359A1	PGDB_A008071	PGDB_C019526	PGDB_AS000700	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025016359A1	PGDB_A019385	PGDB_C019526	PGDB_AS000593	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025016359A1	PGDB_A042866	PGDB_C019526	PGDB_AS002465	View
% Degradation	-	>=	0	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025016359A1	PGDB_A045059	PGDB_C019526	PGDB_AS001647	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2025016359A1	PGDB_A053253	PGDB_C019526	PGDB_AS002547	View
% Inhibition	-	=	30-40	%	500 nM	-	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A067986	PGDB_C019526	PGDB_AS000281	View
% Inhibition	-	=	20-30	%	10 nM	-	IKZF3	-	MDA-MB-231	WO2025016359A1	PGDB_A069799	PGDB_C019526	PGDB_AS000133	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2025016359A1	PGDB_A071174	PGDB_C019526	PGDB_AS001760	View

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