PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Fc1cccc(C2=CCN(Cc3ccc4c(c3)NC4=S)CC2)c1Cl

Compound summary

Compound IDPGDB_C021979

FormulaC19H16ClFN2S

Molecular weight358.869

InChIKeyGADMYNVAAIKJCE-UHFFFAOYSA-N

Physicochemical properties

Exact mass358.0707

RDKit cLogP4.87

TPSA15.3

HBD / HBA1 / 2

Rotatable bonds3

Heavy atoms24

Hetero atoms5

Rings / aromatic4 / 2

Fraction Csp30.21

Formal charge0

Fragments1

Activity compounds and values

Activity records

20 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	80-100	%	500 nM	96 h	-	-	RPMI-8226	CN119654316A	PGDB_A082315	PGDB_C021979	PGDB_AS000560	View
% Degradation	-	=	0-80	%	-	-	GSPT1	-	-	CN119654316A	PGDB_A082609	PGDB_C021979	PGDB_AS000660	View
% Inhibition	-	=	70-80	%	10 nM	96 h	-	-	MOLT-4	CN119654316A	PGDB_A082887	PGDB_C021979	PGDB_AS002038	View
% Inhibition	-	=	50-60	%	10 nM	-	-	-	MM.1S	CN119654316A	PGDB_A083008	PGDB_C021979	PGDB_AS000042	View
% Degradation	-	=	0-80	%	-	-	IKZF2	-	-	CN119654316A	PGDB_A083110	PGDB_C021979	PGDB_AS002430	View
% Inhibition	-	=	80-100	%	10 nM	-	-	-	MV-4-11	CN119654316A	PGDB_A083526	PGDB_C021979	PGDB_AS000053	View
% Inhibition	-	=	60-80	%	2 uM	3 h	CRBN	CRBN	-	CN119654316A	PGDB_A083640	PGDB_C021979	PGDB_AS002552	View
% Degradation	-	=	0-80	%	-	-	IKZF1	-	-	CN119654316A	PGDB_A083775	PGDB_C021979	PGDB_AS001680	View
% Inhibition	-	=	80-100	%	500 nM	96 h	-	-	MOLT-4	CN119654316A	PGDB_A083782	PGDB_C021979	PGDB_AS000121	View
% Degradation	-	=	0-80	%	-	-	IKZF3	-	-	CN119654316A	PGDB_A083820	PGDB_C021979	PGDB_AS000017	View
% Inhibition	-	=	80-100	%	10 nM	96 h	-	-	RPMI-8226	CN119654316A	PGDB_A083864	PGDB_C021979	PGDB_AS001289	View
% Degradation	-	=	0-80	%	-	-	-	-	-	CN119654316A	PGDB_A083875	PGDB_C021979	PGDB_AS000466	View
% Inhibition	-	=	30-40	%	0.5 uM	3 h	CRBN	CRBN	-	CN119654316A	PGDB_A084176	PGDB_C021979	PGDB_AS001405	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	CCRF-CEM	CN119654316A	PGDB_A084337	PGDB_C021979	PGDB_AS002221	View
% Inhibition	-	=	80-100	%	10 nM	-	-	-	CCRF-CEM	CN119654316A	PGDB_A084351	PGDB_C021979	PGDB_AS001358	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MCF-7	CN119654316A	PGDB_A084957	PGDB_C021979	PGDB_AS001118	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MM.1S	CN119654316A	PGDB_A084996	PGDB_C021979	PGDB_AS000639	View
% Degradation	-	=	0-80	%	-	-	WEE1	-	-	CN119654316A	PGDB_A085167	PGDB_C021979	PGDB_AS001023	View
% Inhibition	-	=	0-5	%	10 nM	-	-	-	MCF-7	CN119654316A	PGDB_A085219	PGDB_C021979	PGDB_AS002350	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MV-4-11	CN119654316A	PGDB_A085381	PGDB_C021979	PGDB_AS001323	View

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