PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN119654316A

AssigneeGluetacs Therapeutics Shanghai

TitleCompounds based on thio-glutarimido isoindolinone skeleton and uses thereof

Family ID94281141

Family members3

Filing year2024

Publication date2026-03-05

JurisdictionCN

Compounds457

Activity records3,852

Assays34

Activity compounds and values

Activity records

3,852 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Degradation	-	=	80-100	%	-	-	IKZF2	-	-	PGDB_A081912	PGDB_C022309	PGDB_AS002430	View
IC50	-	>	5	nM	-	—	-	-	Jurkat	PGDB_A081913	PGDB_C022018	PGDB_AS002479	View
% Degradation	-	=	0-80	%	-	-	WEE1	-	-	PGDB_A081914	PGDB_C022200	PGDB_AS001023	View
% Degradation	-	=	80-100	%	-	-	GSPT1	-	-	PGDB_A081915	PGDB_C022154	PGDB_AS000660	View
% Inhibition	-	=	60-80	%	2 uM	3 h	CRBN	CRBN	-	PGDB_A081916	PGDB_C022139	PGDB_AS002552	View
% Degradation	-	=	80-100	%	-	-	IKZF3	-	-	PGDB_A081917	PGDB_C022232	PGDB_AS000017	View
% Inhibition	-	=	53-60	%	0.5 uM	3 h	CRBN	CRBN	-	PGDB_A081918	PGDB_C022400	PGDB_AS001405	View
% Degradation	-	=	0-80	%	-	-	GSPT1	-	-	PGDB_A081919	PGDB_C022076	PGDB_AS000660	View
% Degradation	-	=	0-80	%	-	-	WEE1	-	-	PGDB_A081920	PGDB_C022328	PGDB_AS001023	View
% Degradation	-	=	80-100	%	-	-	IKZF2	-	-	PGDB_A081921	PGDB_C022244	PGDB_AS002430	View
% Degradation	-	=	0-80	%	-	-	IKZF2	-	-	PGDB_A081922	PGDB_C022134	PGDB_AS002430	View
% Inhibition	-	=	40-50	%	500 nM	-	-	-	A375	PGDB_A081923	PGDB_C021996	PGDB_AS001163	View
% Inhibition	-	=	40-53	%	0.5 uM	3 h	CRBN	CRBN	-	PGDB_A081924	PGDB_C022039	PGDB_AS001405	View
% Degradation	-	=	80-100	%	-	-	IKZF2	-	-	PGDB_A081925	PGDB_C022001	PGDB_AS002430	View
% Inhibition	-	=	80-100	%	10 nM	-	-	-	SW620	PGDB_A081926	PGDB_C021998	PGDB_AS001871	View
% Degradation	-	=	80-100	%	-	-	-	-	-	PGDB_A081927	PGDB_C022110	PGDB_AS000466	View
% Degradation	-	=	80-100	%	-	-	-	-	-	PGDB_A081928	PGDB_C022036	PGDB_AS000466	View
% Inhibition	-	=	53-60	%	0.5 uM	3 h	CRBN	CRBN	-	PGDB_A081929	PGDB_C022360	PGDB_AS001405	View
% Inhibition	-	=	30-40	%	10 nM	-	-	-	MV-4-11	PGDB_A081930	PGDB_C022115	PGDB_AS000053	View
% Inhibition	-	=	53-60	%	0.5 uM	3 h	CRBN	CRBN	-	PGDB_A081931	PGDB_C022170	PGDB_AS001405	View

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