PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C=CC1=C(/C=C/CN2CCC(c3ccsc3)CC2)CN(C2CCC(=O)NC2=O)C1=S

Compound summary

Compound IDPGDB_C021988

FormulaC23H27N3O2S2

Molecular weight441.622

InChIKeyBBBRNRSAUJLDMN-ONEGZZNKSA-N

Physicochemical properties

Exact mass441.1545

RDKit cLogP3.41

TPSA52.6

HBD / HBA1 / 5

Rotatable bonds6

Heavy atoms30

Hetero atoms7

Rings / aromatic4 / 1

Fraction Csp30.43

Formal charge0

Fragments1

Activity compounds and values

Activity records

16 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-80	%	-	-	-	-	-	CN119654316A	PGDB_A082049	PGDB_C021988	PGDB_AS000466	View
% Degradation	-	=	0-80	%	-	-	IKZF2	-	-	CN119654316A	PGDB_A082329	PGDB_C021988	PGDB_AS002430	View
% Inhibition	-	=	20-30	%	10 nM	-	-	-	MM.1S	CN119654316A	PGDB_A082650	PGDB_C021988	PGDB_AS000042	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	CCRF-CEM	CN119654316A	PGDB_A082749	PGDB_C021988	PGDB_AS002221	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MV-4-11	CN119654316A	PGDB_A082762	PGDB_C021988	PGDB_AS001323	View
% Inhibition	-	=	30-40	%	10 nM	-	-	-	MV-4-11	CN119654316A	PGDB_A082862	PGDB_C021988	PGDB_AS000053	View
% Inhibition	-	=	60-80	%	2 uM	3 h	CRBN	CRBN	-	CN119654316A	PGDB_A082930	PGDB_C021988	PGDB_AS002552	View
% Degradation	-	=	0-80	%	-	-	GSPT1	-	-	CN119654316A	PGDB_A083318	PGDB_C021988	PGDB_AS000660	View
% Degradation	-	=	80-100	%	-	-	IKZF3	-	-	CN119654316A	PGDB_A083395	PGDB_C021988	PGDB_AS000017	View
% Inhibition	-	=	5-10	%	10 nM	-	-	-	CCRF-CEM	CN119654316A	PGDB_A083687	PGDB_C021988	PGDB_AS001358	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MM.1S	CN119654316A	PGDB_A084288	PGDB_C021988	PGDB_AS000639	View
% Degradation	-	=	0-80	%	-	-	IKZF1	-	-	CN119654316A	PGDB_A084897	PGDB_C021988	PGDB_AS001680	View
% Inhibition	-	=	10-20	%	10 nM	96 h	-	-	MOLT-4	CN119654316A	PGDB_A085224	PGDB_C021988	PGDB_AS002038	View
% Inhibition	-	=	80-100	%	500 nM	96 h	-	-	MOLT-4	CN119654316A	PGDB_A085435	PGDB_C021988	PGDB_AS000121	View
% Degradation	-	=	0-80	%	-	-	WEE1	-	-	CN119654316A	PGDB_A085667	PGDB_C021988	PGDB_AS001023	View
% Inhibition	-	=	53-60	%	0.5 uM	3 h	CRBN	CRBN	-	CN119654316A	PGDB_A085679	PGDB_C021988	PGDB_AS001405	View

Rows per pagePage 1 of 1 · 16 recordsGo to page