PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1cc(C2=CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=S)CC2)cs1

Compound summary

Compound IDPGDB_C021990

FormulaC24H25N3O2S2

Molecular weight451.617

InChIKeyJNQALUOJFUDZTO-UHFFFAOYSA-N

Physicochemical properties

Exact mass451.1388

RDKit cLogP3.64

TPSA52.6

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms31

Hetero atoms7

Rings / aromatic5 / 2

Fraction Csp30.38

Formal charge0

Fragments1

Activity compounds and values

Activity records

20 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-80	%	-	-	WEE1	-	-	CN119654316A	PGDB_A082003	PGDB_C021990	PGDB_AS001023	View
% Inhibition	-	=	80-100	%	500 nM	96 h	-	-	RPMI-8226	CN119654316A	PGDB_A082135	PGDB_C021990	PGDB_AS000560	View
% Degradation	-	=	0-80	%	-	-	IKZF3	-	-	CN119654316A	PGDB_A082366	PGDB_C021990	PGDB_AS000017	View
% Inhibition	-	=	60-80	%	2 uM	3 h	CRBN	CRBN	-	CN119654316A	PGDB_A082500	PGDB_C021990	PGDB_AS002552	View
% Degradation	-	=	0-80	%	-	-	IKZF2	-	-	CN119654316A	PGDB_A082619	PGDB_C021990	PGDB_AS002430	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	CCRF-CEM	CN119654316A	PGDB_A082758	PGDB_C021990	PGDB_AS002221	View
% Inhibition	-	=	10-20	%	10 nM	96 h	-	-	RPMI-8226	CN119654316A	PGDB_A083304	PGDB_C021990	PGDB_AS001289	View
% Degradation	-	=	0-80	%	-	-	GSPT1	-	-	CN119654316A	PGDB_A084096	PGDB_C021990	PGDB_AS000660	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MV-4-11	CN119654316A	PGDB_A084127	PGDB_C021990	PGDB_AS001323	View
% Inhibition	-	=	80-100	%	500 nM	96 h	-	-	MOLT-4	CN119654316A	PGDB_A084248	PGDB_C021990	PGDB_AS000121	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MM.1S	CN119654316A	PGDB_A084349	PGDB_C021990	PGDB_AS000639	View
% Inhibition	-	=	30-40	%	10 nM	-	-	-	CCRF-CEM	CN119654316A	PGDB_A084521	PGDB_C021990	PGDB_AS001358	View
% Degradation	-	=	0-80	%	-	-	IKZF1	-	-	CN119654316A	PGDB_A084702	PGDB_C021990	PGDB_AS001680	View
% Inhibition	-	=	40-60	%	10 nM	-	-	-	MV-4-11	CN119654316A	PGDB_A084788	PGDB_C021990	PGDB_AS000053	View
% Inhibition	-	=	40-50	%	10 nM	-	-	-	MM.1S	CN119654316A	PGDB_A084854	PGDB_C021990	PGDB_AS000042	View
% Degradation	-	=	0-80	%	-	-	-	-	-	CN119654316A	PGDB_A084919	PGDB_C021990	PGDB_AS000466	View
% Inhibition	-	=	40-53	%	0.5 uM	3 h	CRBN	CRBN	-	CN119654316A	PGDB_A085083	PGDB_C021990	PGDB_AS001405	View
% Inhibition	-	=	10-20	%	10 nM	96 h	-	-	MOLT-4	CN119654316A	PGDB_A085222	PGDB_C021990	PGDB_AS002038	View
% Inhibition	-	=	70-80	%	500 nM	-	-	-	MCF-7	CN119654316A	PGDB_A085417	PGDB_C021990	PGDB_AS001118	View
% Inhibition	-	=	0-5	%	10 nM	-	-	-	MCF-7	CN119654316A	PGDB_A085610	PGDB_C021990	PGDB_AS002350	View

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