PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCC(c5cccs5)CC4)ccc3C2=S)C(=O)N1

Compound summary

Compound IDPGDB_C021992

FormulaC23H25N3O2S2

Molecular weight439.606

InChIKeyHIJPXAGEQGSFME-UHFFFAOYSA-N

Physicochemical properties

Exact mass439.1388

RDKit cLogP3.42

TPSA52.6

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms30

Hetero atoms7

Rings / aromatic5 / 2

Fraction Csp30.43

Formal charge0

Fragments1

Activity compounds and values

Activity records

18 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	10-20	%	10 nM	96 h	-	-	MOLT-4	CN119654316A	PGDB_A082326	PGDB_C021992	PGDB_AS002038	View
% Inhibition	-	=	-5-0	%	10 nM	-	-	-	MV-4-11	CN119654316A	PGDB_A082332	PGDB_C021992	PGDB_AS000053	View
% Degradation	-	=	80-100	%	-	-	IKZF3	-	-	CN119654316A	PGDB_A082858	PGDB_C021992	PGDB_AS000017	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MM.1S	CN119654316A	PGDB_A083361	PGDB_C021992	PGDB_AS000639	View
% Inhibition	-	=	30-40	%	0.5 uM	3 h	CRBN	CRBN	-	CN119654316A	PGDB_A083369	PGDB_C021992	PGDB_AS001405	View
% Inhibition	-	=	10-20	%	10 nM	-	-	-	CCRF-CEM	CN119654316A	PGDB_A083929	PGDB_C021992	PGDB_AS001358	View
% Degradation	-	=	0-80	%	-	-	GSPT1	-	-	CN119654316A	PGDB_A083961	PGDB_C021992	PGDB_AS000660	View
% Inhibition	-	=	70-80	%	500 nM	96 h	-	-	RPMI-8226	CN119654316A	PGDB_A084290	PGDB_C021992	PGDB_AS000560	View
% Degradation	-	=	80-100	%	-	-	IKZF2	-	-	CN119654316A	PGDB_A084397	PGDB_C021992	PGDB_AS002430	View
% Inhibition	-	=	80-100	%	500 nM	96 h	-	-	MOLT-4	CN119654316A	PGDB_A084963	PGDB_C021992	PGDB_AS000121	View
% Inhibition	-	=	60-80	%	2 uM	3 h	CRBN	CRBN	-	CN119654316A	PGDB_A084992	PGDB_C021992	PGDB_AS002552	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MV-4-11	CN119654316A	PGDB_A085050	PGDB_C021992	PGDB_AS001323	View
% Degradation	-	=	0-80	%	-	-	-	-	-	CN119654316A	PGDB_A085162	PGDB_C021992	PGDB_AS000466	View
% Degradation	-	=	80-100	%	-	-	IKZF1	-	-	CN119654316A	PGDB_A085255	PGDB_C021992	PGDB_AS001680	View
% Inhibition	-	=	10-20	%	10 nM	-	-	-	MM.1S	CN119654316A	PGDB_A085304	PGDB_C021992	PGDB_AS000042	View
% Inhibition	-	=	10-20	%	10 nM	96 h	-	-	RPMI-8226	CN119654316A	PGDB_A085321	PGDB_C021992	PGDB_AS001289	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	CCRF-CEM	CN119654316A	PGDB_A085594	PGDB_C021992	PGDB_AS002221	View
% Degradation	-	=	0-80	%	-	-	WEE1	-	-	CN119654316A	PGDB_A085711	PGDB_C021992	PGDB_AS001023	View

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