PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CCCC1C(=O)NC(=O)CC1N1Cc2cc(CN3CCC(c4cccc(F)c4Cl)CC3)ccc2C1=S

Compound summary

Compound IDPGDB_C021993

FormulaC28H31ClFN3O2S

Molecular weight528.093

InChIKeyJGGNTTVYVMYCKY-UHFFFAOYSA-N

Physicochemical properties

Exact mass527.181

RDKit cLogP5.18

TPSA52.6

HBD / HBA1 / 4

Rotatable bonds6

Heavy atoms36

Hetero atoms8

Rings / aromatic5 / 2

Fraction Csp30.46

Formal charge0

Fragments1

Activity compounds and values

Activity records

20 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-80	%	-	-	WEE1	-	-	CN119654316A	PGDB_A082005	PGDB_C021993	PGDB_AS001023	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MM.1S	CN119654316A	PGDB_A082063	PGDB_C021993	PGDB_AS000639	View
% Inhibition	-	=	10-18	%	10 nM	-	-	-	MV-4-11	CN119654316A	PGDB_A082157	PGDB_C021993	PGDB_AS000053	View
% Inhibition	-	=	80-100	%	500 nM	96 h	-	-	MOLT-4	CN119654316A	PGDB_A082168	PGDB_C021993	PGDB_AS000121	View
% Inhibition	-	=	10-20	%	10 nM	-	-	-	MCF-7	CN119654316A	PGDB_A082306	PGDB_C021993	PGDB_AS002350	View
% Degradation	-	=	0-80	%	-	-	-	-	-	CN119654316A	PGDB_A082506	PGDB_C021993	PGDB_AS000466	View
% Inhibition	-	=	20-30	%	10 nM	-	-	-	MM.1S	CN119654316A	PGDB_A082692	PGDB_C021993	PGDB_AS000042	View
% Inhibition	-	=	5-10	%	10 nM	-	-	-	CCRF-CEM	CN119654316A	PGDB_A082980	PGDB_C021993	PGDB_AS001358	View
% Inhibition	-	=	30-40	%	0.5 uM	3 h	CRBN	CRBN	-	CN119654316A	PGDB_A083202	PGDB_C021993	PGDB_AS001405	View
% Inhibition	-	=	-5-0	%	10 nM	96 h	-	-	MOLT-4	CN119654316A	PGDB_A083319	PGDB_C021993	PGDB_AS002038	View
% Degradation	-	=	0-80	%	-	-	IKZF2	-	-	CN119654316A	PGDB_A083551	PGDB_C021993	PGDB_AS002430	View
% Inhibition	-	=	70-80	%	500 nM	96 h	-	-	RPMI-8226	CN119654316A	PGDB_A083603	PGDB_C021993	PGDB_AS000560	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MV-4-11	CN119654316A	PGDB_A083713	PGDB_C021993	PGDB_AS001323	View
% Inhibition	-	=	10-20	%	10 nM	96 h	-	-	RPMI-8226	CN119654316A	PGDB_A083772	PGDB_C021993	PGDB_AS001289	View
% Degradation	-	=	0-80	%	-	-	IKZF1	-	-	CN119654316A	PGDB_A084097	PGDB_C021993	PGDB_AS001680	View
% Inhibition	-	=	50-60	%	500 nM	-	-	-	MCF-7	CN119654316A	PGDB_A084538	PGDB_C021993	PGDB_AS001118	View
% Degradation	-	=	0-80	%	-	-	GSPT1	-	-	CN119654316A	PGDB_A084624	PGDB_C021993	PGDB_AS000660	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	CCRF-CEM	CN119654316A	PGDB_A084678	PGDB_C021993	PGDB_AS002221	View
% Degradation	-	=	0-80	%	-	-	IKZF3	-	-	CN119654316A	PGDB_A085530	PGDB_C021993	PGDB_AS000017	View
% Inhibition	-	=	53-60	%	2 uM	3 h	CRBN	CRBN	-	CN119654316A	PGDB_A085668	PGDB_C021993	PGDB_AS002552	View

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