PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C=CC1=C(/C=C/CN2CCC(c3cccc(F)c3F)CC2)CN(C2CCC(=O)NC2=O)C1=S

Compound summary

Compound IDPGDB_C021994

FormulaC25H27F2N3O2S

Molecular weight471.573

InChIKeyBUZZHMBTIGWDBC-SNAWJCMRSA-N

Physicochemical properties

Exact mass471.1792

RDKit cLogP3.63

TPSA52.6

HBD / HBA1 / 4

Rotatable bonds6

Heavy atoms33

Hetero atoms8

Rings / aromatic4 / 1

Fraction Csp30.4

Formal charge0

Fragments1

Activity compounds and values

Activity records

16 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	40-50	%	500 nM	96 h	-	-	RPMI-8226	CN119654316A	PGDB_A082090	PGDB_C021994	PGDB_AS000560	View
% Inhibition	-	=	10-20	%	10 nM	-	-	-	MM.1S	CN119654316A	PGDB_A082093	PGDB_C021994	PGDB_AS000042	View
% Degradation	-	=	0-80	%	-	-	-	-	-	CN119654316A	PGDB_A082183	PGDB_C021994	PGDB_AS000466	View
% Inhibition	-	=	80-100	%	500 nM	96 h	-	-	MOLT-4	CN119654316A	PGDB_A082191	PGDB_C021994	PGDB_AS000121	View
% Degradation	-	=	0-80	%	-	-	IKZF1	-	-	CN119654316A	PGDB_A082354	PGDB_C021994	PGDB_AS001680	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MM.1S	CN119654316A	PGDB_A082496	PGDB_C021994	PGDB_AS000639	View
% Inhibition	-	=	10-20	%	10 nM	96 h	-	-	MOLT-4	CN119654316A	PGDB_A082812	PGDB_C021994	PGDB_AS002038	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	CCRF-CEM	CN119654316A	PGDB_A082970	PGDB_C021994	PGDB_AS002221	View
% Inhibition	-	=	5-10	%	10 nM	-	-	-	CCRF-CEM	CN119654316A	PGDB_A083082	PGDB_C021994	PGDB_AS001358	View
% Degradation	-	=	80-100	%	-	-	IKZF3	-	-	CN119654316A	PGDB_A083266	PGDB_C021994	PGDB_AS000017	View
% Degradation	-	=	0-80	%	-	-	GSPT1	-	-	CN119654316A	PGDB_A083620	PGDB_C021994	PGDB_AS000660	View
% Inhibition	-	=	60-80	%	2 uM	3 h	CRBN	CRBN	-	CN119654316A	PGDB_A084076	PGDB_C021994	PGDB_AS002552	View
% Inhibition	-	=	10-20	%	10 nM	96 h	-	-	RPMI-8226	CN119654316A	PGDB_A084253	PGDB_C021994	PGDB_AS001289	View
% Degradation	-	=	0-80	%	-	-	WEE1	-	-	CN119654316A	PGDB_A084374	PGDB_C021994	PGDB_AS001023	View
% Inhibition	-	=	30-40	%	0.5 uM	3 h	CRBN	CRBN	-	CN119654316A	PGDB_A085051	PGDB_C021994	PGDB_AS001405	View
% Degradation	-	=	0-80	%	-	-	IKZF2	-	-	CN119654316A	PGDB_A085289	PGDB_C021994	PGDB_AS002430	View

Rows per pagePage 1 of 1 · 16 recordsGo to page