PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3c(CN4CCN(c5cccc6sccc56)CC4)cccc3C2=S)C(=O)N1

Compound summary

Compound IDPGDB_C022083

FormulaC26H26N4O2S2

Molecular weight490.654

InChIKeyBLUNEFVZAXLPCE-UHFFFAOYSA-N

Physicochemical properties

Exact mass490.1497

RDKit cLogP3.52

TPSA55.9

HBD / HBA1 / 6

Rotatable bonds4

Heavy atoms34

Hetero atoms8

Rings / aromatic6 / 3

Fraction Csp30.35

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-80	%	-	-	GSPT1	-	-	CN119654316A	PGDB_A081994	PGDB_C022083	PGDB_AS000660	View
% Inhibition	-	=	40-50	%	10 nM	-	-	-	MM.1S	CN119654316A	PGDB_A082359	PGDB_C022083	PGDB_AS000042	View
% Degradation	-	=	80-100	%	-	-	IKZF3	-	-	CN119654316A	PGDB_A082843	PGDB_C022083	PGDB_AS000017	View
% Degradation	-	=	0-80	%	-	-	WEE1	-	-	CN119654316A	PGDB_A083166	PGDB_C022083	PGDB_AS001023	View
% Inhibition	-	=	20-30	%	10 nM	96 h	-	-	RPMI-8226	CN119654316A	PGDB_A083286	PGDB_C022083	PGDB_AS001289	View
% Inhibition	-	=	30-40	%	0.5 uM	3 h	CRBN	CRBN	-	CN119654316A	PGDB_A083500	PGDB_C022083	PGDB_AS001405	View
% Degradation	-	=	80-100	%	-	-	-	-	-	CN119654316A	PGDB_A083630	PGDB_C022083	PGDB_AS000466	View
% Inhibition	-	=	40-50	%	500 nM	96 h	-	-	RPMI-8226	CN119654316A	PGDB_A084171	PGDB_C022083	PGDB_AS000560	View
% Inhibition	-	=	60-70	%	500 nM	-	-	-	MM.1S	CN119654316A	PGDB_A084416	PGDB_C022083	PGDB_AS000639	View
% Degradation	-	=	80-100	%	-	-	IKZF1	-	-	CN119654316A	PGDB_A085148	PGDB_C022083	PGDB_AS001680	View
% Inhibition	-	=	60-80	%	2 uM	3 h	CRBN	CRBN	-	CN119654316A	PGDB_A085170	PGDB_C022083	PGDB_AS002552	View
% Degradation	-	=	80-100	%	-	-	IKZF2	-	-	CN119654316A	PGDB_A085760	PGDB_C022083	PGDB_AS002430	View

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