PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(CN4CCC(c5ccccc5C(F)(F)F)CC4)ccc3C2=S)C(=O)N1

Compound summary

Compound IDPGDB_C022153

FormulaC26H26F3N3O2S

Molecular weight501.574

InChIKeyOEPNDNJYGVJQRK-UHFFFAOYSA-N

Physicochemical properties

Exact mass501.1698

RDKit cLogP4.38

TPSA52.6

HBD / HBA1 / 4

Rotatable bonds4

Heavy atoms35

Hetero atoms9

Rings / aromatic5 / 2

Fraction Csp30.42

Formal charge0

Fragments1

Activity compounds and values

Activity records

14 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	80-100	%	-	-	IKZF1	-	-	CN119654316A	PGDB_A081978	PGDB_C022153	PGDB_AS001680	View
% Inhibition	-	=	30-40	%	0.5 uM	3 h	CRBN	CRBN	-	CN119654316A	PGDB_A082589	PGDB_C022153	PGDB_AS001405	View
% Degradation	-	=	0-80	%	-	-	IKZF2	-	-	CN119654316A	PGDB_A082595	PGDB_C022153	PGDB_AS002430	View
% Inhibition	-	=	10-18	%	10 nM	-	-	-	MV-4-11	CN119654316A	PGDB_A082729	PGDB_C022153	PGDB_AS000053	View
% Inhibition	-	=	10-20	%	10 nM	-	-	-	MM.1S	CN119654316A	PGDB_A082754	PGDB_C022153	PGDB_AS000042	View
% Degradation	-	=	0-80	%	-	-	GSPT1	-	-	CN119654316A	PGDB_A083407	PGDB_C022153	PGDB_AS000660	View
% Inhibition	-	=	-5-0	%	10 nM	96 h	-	-	MOLT-4	CN119654316A	PGDB_A083489	PGDB_C022153	PGDB_AS002038	View
% Inhibition	-	=	70-80	%	500 nM	-	-	-	MM.1S	CN119654316A	PGDB_A083624	PGDB_C022153	PGDB_AS000639	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MV-4-11	CN119654316A	PGDB_A083763	PGDB_C022153	PGDB_AS001323	View
% Degradation	-	=	80-100	%	-	-	WEE1	-	-	CN119654316A	PGDB_A083880	PGDB_C022153	PGDB_AS001023	View
% Degradation	-	=	80-100	%	-	-	-	-	-	CN119654316A	PGDB_A084671	PGDB_C022153	PGDB_AS000466	View
% Inhibition	-	=	80-100	%	500 nM	96 h	-	-	MOLT-4	CN119654316A	PGDB_A084776	PGDB_C022153	PGDB_AS000121	View
% Inhibition	-	=	60-80	%	2 uM	3 h	CRBN	CRBN	-	CN119654316A	PGDB_A085040	PGDB_C022153	PGDB_AS002552	View
% Degradation	-	=	80-100	%	-	-	IKZF3	-	-	CN119654316A	PGDB_A085522	PGDB_C022153	PGDB_AS000017	View

Rows per pagePage 1 of 1 · 14 recordsGo to page