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Compound
PGDB_C022218
10 activity records1 related patents
2D structure
O=C1CCC(N2Cc3cc(CN4CCN(c5cccc(C(F)(F)F)n5)CC4)ccc3C2=S)C(=O)N1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % Inhibition | - | = | 40-60 | % | 500 nM | - | - | - | MV-4-11 | CN119654316A | PGDB_A082039 | PGDB_C022218 | PGDB_AS001323 | View |
| % Inhibition | - | = | -5-0 | % | 10 nM | - | - | - | MV-4-11 | CN119654316A | PGDB_A082277 | PGDB_C022218 | PGDB_AS000053 | View |
| % Degradation | - | = | 80-100 | % | - | - | IKZF2 | - | - | CN119654316A | PGDB_A083040 | PGDB_C022218 | PGDB_AS002430 | View |
| % Degradation | - | = | 80-100 | % | - | - | IKZF1 | - | - | CN119654316A | PGDB_A083123 | PGDB_C022218 | PGDB_AS001680 | View |
| % Inhibition | - | = | 60-80 | % | 2 uM | 3 h | CRBN | CRBN | - | CN119654316A | PGDB_A083971 | PGDB_C022218 | PGDB_AS002552 | View |
| % Inhibition | - | = | 53-60 | % | 0.5 uM | 3 h | CRBN | CRBN | - | CN119654316A | PGDB_A083990 | PGDB_C022218 | PGDB_AS001405 | View |
| % Degradation | - | = | 80-100 | % | - | - | WEE1 | - | - | CN119654316A | PGDB_A084321 | PGDB_C022218 | PGDB_AS001023 | View |
| % Degradation | - | = | 0-80 | % | - | - | - | - | - | CN119654316A | PGDB_A084686 | PGDB_C022218 | PGDB_AS000466 | View |
| % Degradation | - | = | 0-80 | % | - | - | GSPT1 | - | - | CN119654316A | PGDB_A085018 | PGDB_C022218 | PGDB_AS000660 | View |
| % Degradation | - | = | 0-80 | % | - | - | IKZF3 | - | - | CN119654316A | PGDB_A085348 | PGDB_C022218 | PGDB_AS000017 | View |