PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CCN(Cc5ccc(-c6ccc(Cl)cc6)cc5)CC4)c(F)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024385

FormulaC30H29ClFN5O3

Molecular weight562.045

InChIKeyKCJPTOOINBEMIK-UHFFFAOYSA-N

Physicochemical properties

Exact mass561.1943

RDKit cLogP4.05

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms40

Hetero atoms10

Rings / aromatic6 / 3

Fraction Csp30.3

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A012042	PGDB_C024385	PGDB_AS001726	View
% Inhibition	-	=	60-70	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A014313	PGDB_C024385	PGDB_AS000866	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A018756	PGDB_C024385	PGDB_AS000689	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A028462	PGDB_C024385	PGDB_AS002453	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A040242	PGDB_C024385	PGDB_AS000750	View
% Inhibition	-	=	60-70	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A057603	PGDB_C024385	PGDB_AS001140	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A067540	PGDB_C024385	PGDB_AS000091	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A076768	PGDB_C024385	PGDB_AS000351	View

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