PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3c(NN4CCN(CC5=C(c6ccc(F)cc6)CCCC5)CC4)cccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024406

FormulaC30H34FN5O3

Molecular weight531.632

InChIKeyRYYKJHFAGYKPNB-UHFFFAOYSA-N

Physicochemical properties

Exact mass531.2646

RDKit cLogP3.56

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms39

Hetero atoms9

Rings / aromatic6 / 2

Fraction Csp30.43

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A019353	PGDB_C024406	PGDB_AS001561	View
% Inhibition	-	=	30-40	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A022272	PGDB_C024406	PGDB_AS000866	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A023083	PGDB_C024406	PGDB_AS001726	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A028923	PGDB_C024406	PGDB_AS000689	View
% Inhibition	-	=	0-5	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A044180	PGDB_C024406	PGDB_AS001155	View
% Inhibition	-	=	40-50	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A054548	PGDB_C024406	PGDB_AS001140	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A059130	PGDB_C024406	PGDB_AS002453	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A066904	PGDB_C024406	PGDB_AS000351	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A067091	PGDB_C024406	PGDB_AS000091	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A073387	PGDB_C024406	PGDB_AS000750	View

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