PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3ccc(NC4CCN(C(c5ccccc5F)c5ccccc5F)CC4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024409

FormulaC31H28F2N4O4

Molecular weight558.585

InChIKeyPZEWPKFMHORATA-UHFFFAOYSA-N

Physicochemical properties

Exact mass558.2079

RDKit cLogP4.03

TPSA98.8

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms41

Hetero atoms10

Rings / aromatic6 / 3

Fraction Csp30.29

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	50-60	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A013608	PGDB_C024409	PGDB_AS001140	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A017998	PGDB_C024409	PGDB_AS002453	View
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A021289	PGDB_C024409	PGDB_AS000866	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A025603	PGDB_C024409	PGDB_AS000750	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A053724	PGDB_C024409	PGDB_AS000689	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A062814	PGDB_C024409	PGDB_AS000091	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A068241	PGDB_C024409	PGDB_AS001726	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A071472	PGDB_C024409	PGDB_AS000351	View

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