PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3c(NN4CCN(C(c5ccccc5F)c5ccccc5F)CC4)cccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024411

FormulaC30H29F2N5O3

Molecular weight545.59

InChIKeyMFUZJJQRSIUAHK-UHFFFAOYSA-N

Physicochemical properties

Exact mass545.2238

RDKit cLogP3.46

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms40

Hetero atoms10

Rings / aromatic6 / 3

Fraction Csp30.3

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	60-70	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A008420	PGDB_C024411	PGDB_AS000866	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A009988	PGDB_C024411	PGDB_AS002453	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A015352	PGDB_C024411	PGDB_AS000689	View
% Inhibition	-	=	50-60	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A021293	PGDB_C024411	PGDB_AS001155	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A026616	PGDB_C024411	PGDB_AS001726	View
% Inhibition	-	=	70-80	%	500 nM	96 h	IKZF3	-	MM.1S	WO2025162225A1	PGDB_A029904	PGDB_C024411	PGDB_AS001942	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A030987	PGDB_C024411	PGDB_AS000091	View
% Inhibition	-	=	60-70	%	10 nM	96 h	IKZF3	-	MM.1S	WO2025162225A1	PGDB_A036524	PGDB_C024411	PGDB_AS002484	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A049138	PGDB_C024411	PGDB_AS000351	View
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A056173	PGDB_C024411	PGDB_AS001561	View
% Inhibition	-	=	60-70	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A059507	PGDB_C024411	PGDB_AS001140	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A060238	PGDB_C024411	PGDB_AS000750	View

Rows per pagePage 1 of 1 · 12 recordsGo to page