PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CC1(C)CC(c2ccc(Cl)cc2)=C(CN2CCN(Nc3cc4c(cc3F)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)CO1

Compound summary

Compound IDPGDB_C024414

FormulaC31H33ClFN5O5

Molecular weight610.086

InChIKeyGSBDURUUZDDQMX-UHFFFAOYSA-N

Physicochemical properties

Exact mass609.2154

RDKit cLogP3.48

TPSA111.3

HBD / HBA2 / 8

Rotatable bonds6

Heavy atoms43

Hetero atoms12

Rings / aromatic6 / 2

Fraction Csp30.42

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	40-50	%	10 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A008064	PGDB_C024414	PGDB_AS001140	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A012690	PGDB_C024414	PGDB_AS000351	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A023147	PGDB_C024414	PGDB_AS000091	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A038420	PGDB_C024414	PGDB_AS000689	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A047580	PGDB_C024414	PGDB_AS002453	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A050130	PGDB_C024414	PGDB_AS000750	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A056561	PGDB_C024414	PGDB_AS001726	View
% Inhibition	-	=	30-40	%	500 nM	96 h	IKZF3	-	H196	WO2025162225A1	PGDB_A069914	PGDB_C024414	PGDB_AS000866	View

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